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james_davis_nicoll
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fancake22degreehalo posting in fancakeboomchick22degreehalo posting in fancakemarquisguyunmdlbearToday is Isaac Newton's Birthday, so I'd like to start by wishing you all a very Heavy Newtonmas. I am thankful for...
selenakDemerzel wanted to scream back at him, to explain how this was all his fault, Cleon the First damning them all to this nightmare fate that none of them could escape.
But she said nothing, and walked away. Like she always did.
He can’t get a rise out of her, and can never push hard enough that she pushes back. Human mothers eventually raise their voices, yell back, get upset. You can fling hurtful words at a human mother. But as far as he can tell, it never lands with Demerzel; there’s no heart there to twist the knife into.
(Relationship study for what slowly went wrong between Cleon XXIV and Demerzel. Spoilers for all of season 3.)
sovay
cornerofmadness
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scalziwhatever_feed
My senior year of college, I was invited by the Dartmouth Alumni Magazine to come and write a story about the college’s Green Key Weekend, a weekend of partying and games and partying and also partying with partying on the side (why did they invite me? Because I was from the famously unfun University of Chicago, and they wanted to see what the weekend looked like from the view of an outsider with that sort of perspective).
There was much of the weekend I don’t remember (ahem), but one thing that sticks in my mind is the Spring Sing concert, in which the several acapella groups of Dartmouth got together and did their thing. I thought they were all fantastic, and also, during the concert there was one girl who took a penny, balanced it on the end of a stretched-out wire coat hanger and spun it, keeping it stuck on the end of that coat hanger while singing the Toy R’ Us jingle, backward. I remember thinking this was the most hilariously amazing thing I’d ever seen, and also, I wanted to marry that girl, whoever she was.
Spoiler: I did not marry her. But neither has a year gone by that I have not thought about her and wondered what she was doing with her life now. We don’t always pick the things we remember. They make an impression nevertheless.
It is perhaps this personal history with acapella that primed me to enjoy Pitch Perfect as much as I did. It is a very silly film about something that doesn’t have much consequence, namely, the hyper-competitive college acapella circuit. This is obscure to the real world (or was, until this film), but is life-or-death to the theater-adjacent-kids who yearn to get out and sing without instrumental accompaniment. I first watched Pitch Perfect not expecting much, and came away having laughed more than I thought I would, and having been unexpectedly moved in a couple of places.
The plot: Beca (Anna Kendrick) is a jaded wanna-be DJ attending Barden University, mostly because her dad’s on the faculty so presumably she’s getting a tuition discount. She mostly wants to work at the college radio station and focus on her remixes, but one day Chloe (Brittany Snow) hears her singing in the shower and basically dragoons her into auditioning for the Barton Bellas, a once-proud all-girl acapella group now struggling because of an infamous event at the previous year’s national competition (which I will not relate, you will see it soon enough if you watch the film).
Beca auditions, gets in and immediately butts heads with Aubrey (Anna Camp), the group’s type-a leader, who wants to do things just so. Beca wants to loosen things up, whether everyone else agrees or not, and eventually there’s a battle of wills for the future of the group, interspersed with various competitions and run-ins with the Treblemakers, Barden’s all-male acapella group, who include Jesse (Skylar Astin), a fellow freshman who is sweet on Beca more than Beca is sweet on him.
Truth to tell, Beca is not a hugely sympathetic main character, even if she is played winningly by Kendrick. Beca gets a lot of mileage out of not being a joiner and being her own person, but mostly it just means she’s unhappy and maybe a little miserable to be around, and causes more trouble than needs to be caused. This is not bad for the movie, since it precipitates at least a couple of amusing scenes (including an acapella rumble, which is as ridiculous as it sounds). It does make you wonder what everyone in this film sees in her. Usually when someone is this casually dismissive of everyone and everything, you just let them get on with being their own little ball of gloom.
But no, the film and its characters are determined to pull her out of her shell, mostly because otherwise there wouldn’t be much of a movie, but also because they intuit that Beca’s lone wolf act is just that, an act. She likes being part of a group, and having friends, and being someone that others can rely on. The question for the movie is whether all of that can be achieved through the power of song, and whether Beca’s own particular set of musical skills will come into play. Inasmuch as this is a crowd-pleasing comedy, you will get no points for guessing how it’s all going to turn out.
No points, but that doesn’t mean it’s not still fun and even affecting. Acapella doesn’t mean anything in the real world, but there are worse things to get wrapped up in as a college-age person, and there’s something to be said about the joy you can have, getting into the same groove as all your friends. This movie is a jukebox musical and all the music is diegetic, but when you’re with a group of people who will naturally burst into song just because they feel like it, that diegetic nature doesn’t feel materially different from a standard musical. There’s something winning about a bunch of people just singing because, you know, why not? Why not sing? Even Beca eventually gives in to it. The power of pop compels her!
Naturally this all leads up to the movie’s final musical performance, where Beca has come up with a way to bring the underdog Bellas back to glory. I don’t know enough about the state of collegiate acapella in the early 2010s to know if what occurs here is an actual innovation or just the film reinventing the musical wheel, but at that point I also didn’t care. It’s a banger of a performance, so full of music nerd energy that I couldn’t help but smile all the way through it, and maybe even tear up (I am a weeper, deal with it). As musical payoffs go, it’s a winner.
Does the world change because of it? Not really, no. But not everything has to change the world. Sometimes just saving a dour little freshman from her own self-imposed alienation is enough. And in the meantime, the movie packs in a lot of snark along with the songs, thanks to a fun script, a very funny supporting cast (including Rebel Wilson in her star-making role), and a greek chorus in the form of two acapella color commentators (John Michael Higgins and Elizabeth Banks, the latter of whom also produced, and who would direct the sequel). It even made a pop star out of Anna Kendrick, as “Cups,” a version of a song she performed in the film, went to number 6 on the Billboard Hot 100 chart.
Pitch Perfect was a moderate-sized hit at the box office and blossomed in home video. Its two successors were box office smashes and there was even a TV series spin-off that detailed the adventures of a Treblemaker named Bumper (Adam DeVine) following up a fluke hit in Germany. None of these quite had the magic of the original, but they didn’t have to have that full measure of magic. Turns out people just seem to enjoy low-stakes comedy with a lot of music thrown in. I’m somewhat surprised that this film hasn’t yet been turned into a Broadway musical. If ever there was a property designed for the a long Broadway run as a tourist favorite followed by an eternal life as a touring show, it is this one. I suspect it’s a question of when, not if.
I watch Pitch Perfect when I need a little pick-me-up, because it’s fun, it has music, and inevitably it makes me smile. I suspect I am not alone in this assessment; I imagine every single acapella kid ever feels the same way, up to and including that penny-swinging, backwards-Toys-R-Us-theme-song singing girl. I know she’s still out there. I bet she loves this film to death.
— JS
(PS: If you want to read that story I wrote about Dartmouth’s Green Key Weekend, 34 years ago now, it’s here.)
prixmiumfandomcalendar and picked out any and everything that's current that I even might be interested or equipped to do. There are a few things I skipped either because of parameters, dates, or fandoms I'm not in, but here's what I found: moodthemeinayear. I'm not as visual as I am interested in writing and sound, but sometimes I take a notion, and this requires less independent creativity from me, so I might give it a shot if I take a notion. beagoldfish. 
comment_bingo. This round is open until the end of March. Challenging oneself to go around leaving comments on others' works. I could use some guidance with how to go about participating in fandom in the reader direction as well. I comment on almost everything I read, but I get choice paralysis or am bad at searching and don't read as much as I could. candyheartsex - Candy Hearts Exchange - "Candy Hearts is a multifandom gift exchange with a low minimum and a focus on relationships, both platonic and romantic/sexual." - Nominations are still open for a couple of days, which is one thing that draws me to this! traumaticexperiences is a 1k minimum exchange focused on characters' traumatic experiences. All fandoms allowed except RPF. Nominations starting on the 30th.
merrileemakes posting in booknook
A special issue featuring reprints by neurodivergent creators from Reckoning’s first decade.
Essays, poetry, fiction, and art by Oluwatomiwa Ajeigbe, E.C. Barrett, Kaye Boesme, Offor Chidera, Jacob Coffin, Kelsey Day, Tania Fordwalker, Abbie Goldberg, A.P. Golub, Ruth Joffre, Taylor Jones, Laura McKnight, Kat Murray, Micah Nemerever, Mari Ness, Ellis Nye, Maria S. Picone, T.K. Rex, Ariadne Starling, and Adam Stemple, with new cover artwork by Abi Stevens.
low_delta posting in birdfeedingrolanniSo here I am in the comfy chair: Listening to music, checking email, and basking in the Happy Lite.
Several kind people sent me tea over the last few days, and I now rejoice in two infusers, where I previously had none. This morning, in celebration of the weather, I am enjoying Russian Caravan tea.
Ah..."and all the bad boys are standing in the shadows/and all the good girls are home with broken hearts."
The Long Back Yard
#
Taking a break to do PT homework, start washing the curtains and take out some chicken breasts to hopefully defrost in time to be cooked for tomorrow's lunch and! follow up baked chicken sandwiches. The Forbidden Food List includes all lunch meats and ... that's an ongoing hardship. But, there's no prohibition against sliced chicken off a home-cooked breast.
It's still snowing a bit, and I'm measuring just 5 inches on the deck.
UPS is still insisting it's making a delivery today, and I found a place to tell the driver to PUT THE BOX IN THE GARAGE, and I opened the garage door. Fingers crossed.
I got an automated call saying that the local Senior Center, which serves lunch to a good many people, is closed today on account of Weather. Reopening on Friday. I hope everybody who depends on that lunch is OK.
I've explored the new door configuration again and what I think is that I need to go to Home Despot next week and Stare at Stuff.
The cats are Visibly Relieved to have their Safe Room back. The last couple days were tense for all of us. But! It's behind us now. Just gotta settle the bill. (eek! and yes, I can settle the bill, and I don't depend on the Senior Center for lunch. Which makes me a very fortunate woman.)
How's everybody doing today?
#
Well done UPS!
The Ring went off, which meant that somebody had approached the front door, and I said to Rookie and Tali as I got up from my keyboard. "That's UPS, and they didn't put in the garage."
There was a car in the driveway when I got to the door, and the box was on the front step, and I was opening the door, when the driver of the car got out, and came rushing back to me, "I'm so sorry; I only just saw that you wanted it in the garage. I'm really sorry."
And I said, "Thank you for coming back. Since you got it this far, can you just put it inside the door?"
"Oh, yes. I can certainly do that! I'm sorry."
And he put the box in the house; we exchanged Happy Holidays and he drove off.
So, praise where earned. Well-done, UPS!
And in fact, this is what was in the box:
: 
#
Wrote +/-1160 words today, and reviewed several scenes that I considered "problematical,"which are, in fact, perfectly fine and actually do belong in this book. The WIP entire is more or less 112,200 words.
Coon Cat Happy Hour has occurred. I have discovered that I bought some frozen dumplings, and that will be my evening meal. Tomorrow, my intention is to write and to bake a loaf of bread, perhaps not even in that order.
Everybody have a good evening. Stay safe. I'll be around tomorrow.
Oh! Today's blog post title from Mr. Thomas Petty, "Free fallin'"
sidereaBy examining both human Alzheimer's brain tissue and multiple preclinical mouse models, the team identified a key biological failure at the center of the disease. They found that the brain's inability to maintain normal levels of a critical cellular energy molecule called NAD+ plays a major role in driving Alzheimer's. Importantly, maintaining proper NAD+ balance was shown to not only prevent the disease but also reverse it in experimental models.
Why This Approach Differs From Supplements
Dr. Pieper cautioned against confusing this strategy with over the counter NAD+-precursors. He noted that such supplements have been shown in animal studies to raise NAD+ to dangerously high levels that promote cancer. The method used in this research relies instead on P7C3-A20, a pharmacologic agent that helps cells maintain healthy NAD+ balance during extreme stress, without pushing levels beyond their normal range.
NAD+ levels naturally decline throughout the body, including the brain, as people age. When NAD+ drops too low, cells lose the ability to carry out essential processes needed for normal function and survival. The researchers discovered that this decline is far more severe in the brains of people with Alzheimer's. The same pattern was seen in mouse models of the disease.Note, potential conflict of interest: the head of the lab, Dr Pieper, above, has a serious commercial interest in this proving out:
[...]
Amyloid and tau abnormalities are among the earliest and most significant features of Alzheimer's. In both mouse models, these mutations led to widespread brain damage that closely mirrors the human disease. This included breakdown of the blood-brain barrier, damage to nerve fibers, chronic inflammation, reduced formation of new neurons in the hippocampus, weakened communication between brain cells, and extensive oxidative damage. The mice also developed severe memory and cognitive problems similar to those seen in people with Alzheimer's.
[...]
This approach built on the group's earlier work published in Proceeding of the National Academy of Sciences USA, which showed that restoring NAD+ balance led to both structural and functional recovery after severe, long-lasting traumatic brain injury. In the current study, the researchers used a well-characterized pharmacologic compound called P7C3-A20, developed in the Pieper laboratory, to restore NAD+ balance.
The results were striking. Preserving NAD+ balance protected mice from developing Alzheimer's, but even more surprising was what happened when treatment began after the disease was already advanced. In those cases, restoring NAD+ balance allowed the brain to repair the major pathological damage caused by the genetic mutations.
Both mouse models showed complete recovery of cognitive function. This recovery was also reflected in blood tests, which showed normalized levels of phosphorylated tau 217, a recently approved clinical biomarker used to diagnose Alzheimer's in people. These findings provided strong evidence of disease reversal and highlighted a potential biomarker for future human trials.
The technology is currently being commercialized by Glengary Brain Health, a Cleveland-based company co-founded by Dr. Pieper.The actual research article:
Abstract:Full text here: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1
Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.
rolanni64 A Gentleman of Questionable Judgement (Lord Julian #9), Grace Burrowes (e)
63 Peacock on Parade (Shamrock Safari Shifters), Murphy Lawless writing as Zoe Chant (e)
62 The Besotted Baron (Bad Heir Days #4), Grace Burrowes (e)
61 Storm Called, (Royal States #1) Susan Copperfield (e)
60 That the Dead May Rest, Karen A. Wylie (e)
59 Emilie and the Sky World,(Emilie Adventures#2) Martha Wells (e)
58 The Thursday Murder Club, Richard Osman (e) (bkclb)
57 The Bookshop of Dust and Dreams, Mindy Thompson (e)
56 Remarkably Bright Creatures, Shelby Van Pelt (e) (bkclb)
55 Hunting Ground, Patricia Briggs (Alpha&Omega 2)(re-read) (e)
54 Cry Wolf, Patricia Briggs (Alpha & Omega 1) (re-read) (e)
53 Alpha and Omega, Patricia Briggs (Alpha&Omega.5(re-read) (e)
52 Blind Date with a Werewolf, Patricia Briggs (e)
51 The Women, Kristin Hannah (e) (bkclb)
50 Emilie and the Hollow World, (Emilie Adventures #1) Martha Wells (e)
49 Black Tie & Tails (Black Wolves of Boston #2), Wen Spencer (e)
48 Shards of Earth, Adrian Tchaikovsky(The Final Architecture #1)e)
47 Hemlock and Silver, T. Kingfisher (e)
46 Outcrossing, Celia Lake (Mysterious Charm #1) (e)
45 Outfoxing Fate, Zoe Chant/Murphy Lawless (Virtue Shifters)(e)
44 Atonement Sky, Nalini Singh (Psy-Changeling Trinity #9) (e)
43 Stone and Sky, Ben Aaronovitch (Rivers of London #10) (e)
42 Regency Buck, Georgette Heyer (re-re-re-&c-read)
41 I Dare, Sharon Lee and Steve Miller (Liaden Universe #7) (page proofs)
40 To Hive and to Hold, Amy Crook (The Future of Magic #1) (e)
39 These Old Shades, Georgette Heyer, narrated by Sarah Nichols (re-re-re-&c-read, 1st time audio)
38 Faking it (Dempsey Family #2), Jennifer Crusie, narrated by Aasne Vigesaa (re-re-re-&c-read, 1st time audio)
37 Copper Script, K.J. Charles (e)
36 The Masqueraders, Georgette Heyer, narrated by Eleanor Yates (re-re-re-&c-read; 1st time audio)
35 Everyone Here Spoke Sign Language: Hereditary Deafness on Martha's Vineyard, Nora Ellen Groce (e)
34 Miss Pettigrew Lives for a Day, Winifred Watson, narrated by Frances McDormand (re-re-re-&c-read; 1st time audio)
33 The Wings upon Her Back, Samantha Mills (e)
32 Death on the Green (Dublin Driver #2), Catie Murphy (e)
31 The Elusive Earl (Bad Heir Days #3), Grace Burrowes (e)
30 The Mysterious Marquess (Bad Heir Days #2), Grace Burrowes (e)
29 Who Will Remember (Sebastian St. Cyr #20), C.S. Harris (e)
28 The Teller of Small Fortunes, Julie Leong (e)
27 Check and Mate, Ali Hazelwood (e)
26 The Dangerous Duke (Bad Heir Days #1), Grace Burrowes (e)
25 Night's Master (Flat Earth #1) (re-read), Tanith Lee (e)
24 The Honey Pot Plot (Rocky Start #3), Jennifer Crusie and Bob Mayer (e)
23 Very Nice Funerals (Rocky Start #2), Jennifer Crusie and Bob Mayer (e)
22 The Orb of Cairado, Katherine Addison (e)
21 The Tomb of Dragons, (The Cemeteries of Amalo Trilogy, Book 3), Katherine Addison (e)
20 A Gentleman of Sinister Schemes (Lord Julian #8), Grace Burrowes (e)
19 The Thirteen Clocks (re-re-re-&c read), James Thurber (e)
18 A Gentleman Under the Mistletoe (Lord Julian #7), Grace Burrowes (e)
17 All Conditions Red (Murderbot Diaries #1) (re-re-re-&c read) (audio 1st time)
16 Destiny's Way (Doomed Earth #2), Jack Campbell (e)
15 The Sign of the Dragon, Mary Soon Lee
14 A Gentleman of Unreliable Honor (Lord Julian #6), Grace Burrowes (e)
13 Market Forces in Gretna Green (#7 Midlife Recorder), Linzi Day (e)
12 Shakespeare: The Man Who Pays the Rent, Judi Dench with Brendan O'Hea (e)
11 Code Yellow in Gretna Green (#6 Midlife Recorder), Linzi Day (e)
10 Seeing Red in Gretna Green (#5 Midlife Recorder), Linzi Day (e)
9 House Party in Gretna Green (#4 Midlife Recorder), Linzi Day (e)*
8 Ties that Bond in Gretna Green (#3 Midlife Recorder), Linzi Day (e)
7 Painting the Blues in Gretna Green (#2 Midlife Recorder), Linzi Day (e)
6 Midlife in Gretna Green (#1 Midlife Recorder), Linzi Day (e)
5 The Goblin Emperor, Katherine Addison (Author), Kyle McCarley (Narrator) re-re-re&c-read (audio)
4 The House in the Cerulean Sea, TJ Klune (e)
3 A Gentleman in Search of a Wife (Lord Julian #5) Grace Burrowes (e)
2 A Gentleman in Pursuit of the Truth (Lord Julian #4) Grace Burrowes (e)
1 A Gentleman in Challenging Circumstances (Lord Julian #3) Grace Burrowes (e)
_____
*Note: The list has been corrected. I did not realize that the Gretna Green novella was part of the main path, rather than a pleasant discursion, and my numbering was off. All fixed now.
kaberett... which meant I thought it was very funny when later said afternoon I became aware that there's ongoing scrutiny of their operations from the Business and Trade Committee (first link I could find, it's bedtime). Also very funny that the time from name change to shed legacy of being Awful to Nah You're Still Awful was approximately -5, on a more national scale than I'd previously clocked...
james_davis_nicoll - Culturally appropriate seasonal wishes or lack thereof, according to your chosen norms!selenak - Colour in the Bleakest Midwinterprofiterole_reads - Merry Christmas!22degreehalo in fancake - MGS: Rat in a Foxhole by thelonebamf22degreehalo in fancake - SVSSS: blood, leave no stain by Boomchick22degreehalo in fancake - SVSSS: the future is a foreign country by marquisguyunmdlbear - Thankful Thursday (Special Newtonmas edition)selenak - Yuletide!dine - hope you have a Christmas, and a very New Yearapod_feed - (no subject)sovay - Plates will shift and the earth will groancornerofmadness - Christmas Evescalziwhatever_feed - The December Comfort Watches 2025, Day Twenty-Four: Pitch Perfectprixmium - Possible Fannish Activitesmerrileemakes in booknook - Review: A Chorus, Divergent anthologylow_delta in birdfeeding - goldfinchesrolanni - (no subject)siderea - Merry Christmas: Scientists reverse Alzheimer's in mice [sci/bio/med]rolanni - Books read in 2025kaberett - today EVRi actually managed to deliver a parcel, not only on time but early
